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The model-adjusted change from baseline in HbA1c at week 52 was significantly better with albiglutide than with placebo (-0.
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Population-average models estimate the effects at different vitamin E dosages averaged across all trials, whereas robust standard errors are relatively insensitive to model misspecification.
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Treatment with pioglitazone as add-on to sulfonylurea produced statistically significant improvements in HbA1c and FPG at endpoint compared to placebo add-on to sulfonylurea (see Table 20).
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The rarity of the outcome limited the number of variables in the multiple regression analysis, and whether nonsignificant interactions were true or caused by insufficient statistical power remains uncertain.
As shown in Table 10 and Figure 1, at the end of treatment, INVOKANA 100 mg provided similar reductions in HbA1C from baseline compared to glimepiride when added to metformin therapy.
These trials examined pioglitazone hydrochloride at doses up to 45 mg or placebo once daily in a total of 865 patients.
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Descriptive statistics were used to summarise the characteristics of pioglitazone users, rosiglitazone users, and non-thiazolidinedione users at cohort entry.
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Monitor for signs and symptoms after initiating therapy.
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In addition, high-dosage vitamin E trials were often performed in patients with various chronic diseases, and we could not evaluate the generalizability of our findings to healthy adult populations.
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When glycemic control can no longer be maintained with monotherapy, additional therapies are required, but several of the agents used as second-line treatment are associated with tolerability issues, such as gastrointestinal side effects, hypoglycemia, and weight gain ().
NovoMix 30 gave almost identical results to biphasic human insulin 30 at the end of the studies.
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There have been postmarketing reports of acute kidney injury, some requiring hospitalization and dialysis, in patients receiving INVOKANA; some reports involved patients younger than 65 years of age.
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